标题:新型钆纳米载体在肝靶向分子磁共振显影对比剂中的应用
作者:刘永军;陈智金;张娜
作者机构:山东大学药学院,山东济南,250012
通讯作者:Zhang, N(zhangnancy9@sdu.edu.cn)
通讯作者地址:[Zhang, N] School of Pharmaceutical Science, Shandong University, 250012 Ji'nan, China;
来源:中国药学(英文版)
出版年:2011
卷:20
期:2
页码:105-117
DOI:10.5246/jcps.2011.02.013
关键词:肝细胞癌(HCC);分子显影;对比剂;钆(Gd);磁共振显影(MRI)
摘要:Accurate diagnosis of hepatocellular carcinoma (HCC) in the early stage is vital for its treatment. Contrastenhanced dynamic magnetic resonance imaging (MRI) performed in the presence of extracellular contrast agents such as gadolinium chelates is considered as a useful approach for detecting and characterizing focal liver lesions. However, the sensitivity and specificity of conventional MRI contrast agents are far from satisfaction for the detection and characterization of benign and malignant focal liver lesions in the early stage. The novel molecular contrast agents special for liver with relatively longer metabolic time and stable contrast effect in liver tissue are highly desired. The development of nanotechnology provides an unprecedented opportunity for the diagnostic detection rate of HCC and cellsurface receptortargeted nanotechnology improves the specificity of the detection of focal liver lesions. In order to maximize lesion detection and characterization, novel gadolinium chelates loaded nanovectors including the solid lipid nanoparticles, nanocomplexes and polymeric nanoparticles have been used as biocompatible molecular MRI contrast agent. In this review, the characterization and the advantages/disadvantages of these Gdloaded novel nanovectors used as molecular MRI contrast agents were discussed. Furthermore, liver target nanovectors aimed at improving the diagnostic accuracy of liver MRI by targeting additional features of focal liver lesions were highlighted. © 2011 Journal of Chinese Pharmaceutical Sciences.
收录类别:SCOPUS
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84860789343&doi=10.5246%2fjcps.2011.02.013&partnerID=40&md5=da53d7a3054242078bb1eebc2bc5be2e
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