标题：Transmission Routes Analysis of SARS-CoV-2: A Systematic Review and Case Report
作者：Li, Huanjie; Wang, Yangyang; Ji, Mingyu; Pei, Fengyan; Zhao, Qianqian; Zhou, Yunying; Hong, Yatian; Han, Shuyi; Wang, Jun; Wang, Qin 更多 作者机构：[Li, Huanjie; Wang, Yangyang; Wang, Yunshan] Shandong Univ, Sch Med, Cheeloo Coll Med, Jinan, Peoples R China.; [Li, Huanjie; Ji, Mingyu; Pei, Fengy 更多
通讯作者地址：Li, HJ; Wang, YS (corresponding author), Shandong Univ, Sch Med, Cheeloo Coll Med, Jinan, Peoples R China.; Li, HJ; Wang, YS (corresponding author), S 更多
来源：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
关键词：SARS-CoV-2; transmission routes; eyes-oral transmission; asymptomatic; patients; COVID-19
摘要：The global outbreak of SARS-CoV-2 spread rapidly throughout the world which transmitted among humans through various routes. Asymptomatic (carriers) and possible fecal-oral transmission, resulted into a large-scale spread. These issues pose great challenges to disease diagnosis and epidemic control. We obtained data on 29 cases of COVID-19 patients in Jinan, China, and reported the clinical data of asymptomatic patients confirmed with stool samples positive. Some patients with gastrointestinal infections are secondary to pulmonary infections, and during the patients' recovery period, the virus may still existin the patient's gastrointestinal tract over 7 days. We combined with epidemiological and clinical data of asymptomatic patients to analyze the possible routes of viral transmission and infection, including eyes-nose, hands-eyes, fecal-oral, and eyes-oral, et al., thus first presented the two-way transmission through eyes-oral. Through associating infection symptoms with the transmission routes of virus and the patient course of the disease, we expect to provide guidelines for clinical diagnosis and the basis for suppressing the spread of the virus and antiviral treatment.