标题：Depressive Symptom Clusters and Their Relationships With Anxiety and Posttraumatic Stress Disorder Symptoms in Patients With Cancer The Use of Latent Class Analysis
作者：Li, Jie; Zhang, Huihui; Shao, Di; Xue, Jiaomei; Bai, Huayu; Sun, Jiwei; Lin, Pingzhen; Cao, Fenglin
作者机构：[Li, Jie; Zhang, Huihui; Shao, Di; Xue, Jiaomei; Bai, Huayu; Sun, Jiwei; Lin, Pingzhen; Cao, Fenglin] Shandong Univ, Sch Nursing, 44 Wenhuaxi Rd, Jina 更多
通讯作者地址：[Cao, FL]Shandong Univ, Sch Nursing, 44 Wenhuaxi Rd, Jinan, Shandong, Peoples R China.
关键词：Anxiety; Cancer; Cluster; Depressive symptom; Latent class analysis;; Oncology; Posttraumatic stress disorder
摘要：Background Depressive symptoms are prevalent in patients with cancer and are heterogeneous; however, existing methods of grouping patients with heterogeneous symptoms have limitations. Objectives The purpose of this study was to identify depressive symptom clusters in patients with cancer using a data-driven method and to explore their relationships with symptoms of anxiety and posttraumatic stress disorder. Methods Data from 247 patients were analyzed in this cross-sectional study. Latent class analysis was used to identify depressive symptom clusters, using 9 depressive symptoms from the Patient Health Questionnaire. Symptoms of anxiety and posttraumatic stress disorder were measured, and the relationships between them and the clusters were explored through linear regression analyses. Results Four clusters of depressive symptoms were identified: (1) minimal with sleep and appetite disturbances (23.9%), (2) somatic (22.3%), (3) moderate with sleep disturbance and fatigue (32.4%), and (4) severe (21.5%). The order of severity of anxiety and posttraumatic stress disorder symptoms was comparable across the 4 clusters of depressive symptoms. The anxiety and posttraumatic stress disorder symptoms of patients in clusters 3 and 4 were more severe than those in cluster 1 (B = 4.70-19.19, P < .001). Conclusion Using latent class analysis, 4 clusters of depressive symptoms were identified in patients with cancer, which were significantly correlated with symptoms of anxiety and posttraumatic stress disorder.