标题：Novel star-type methoxy-poly(ethylene glycol) (PEG)-poly(Ε- caprolactone) (PCL) copolymeric nanoparticles for controlled release of curcumin
作者：Feng, Runliang ;Zhu, Wenxia ;Song, Zhimei ;Zhao, Liyan ;Zhai, Guangxi
作者机构：[Feng, Runliang ;Zhu, Wenxia ;Song, Zhimei ] Department of Pharmaceutical Engineering, University of Jinan, Shandong Academy of Medical Science, 106 J 更多
来源：Journal of Nanoparticle Research
摘要：To improve curcumin's (CURs) water solubility and release property, a novel star methoxy poly(ethylene glycol)-poly(Ε-caprolactone) (MPEG-PCL) copolymer was synthesized through O-alkylation, basic hydrolysis and ring-opening polymerization reaction with MPEG, epichlorohydrin, and Ε-caprolactone as raw materials. The structure of the novel copolymer was characterized by1H NMR, FT-IR, and GPC. The results of FT-IR and differential scanning calorimeter of CUR-loaded nanoparticles (NPs) prepared by dialysis method showed that CUR was successfully encapsulated into the SMP12 copolymeric NPs with 98.2 % of entrapment efficiency, 10.91 % of drug loading, and 88.4 ± 11.2 nm of mean particle diameter in amorphous forms. The dissolubility of nanoparticulate CUR was increased by 1.38 × 105times over CUR in water. The obtained blank copolymer showed no hemolysis. A sustained CUR release to a total of approximately 56.13 % was discovered from CUR-NPs in 40 % of ethanol saline solution within 72 h on the use of dialysis method. The release behavior fitted the ambiexponent and biphasic kinetics equation. In conclusion, the copolymeric NPs loading CUR might serve as a potential nanocarrier to improve the solubility and release property of CUR. © 2013 Springer Science+Business Media Dordrecht.