标题:Characterization of sFRP2-like in amphioxus: Insights into the evolutionary conservation of Wnt antagonizing function
作者:Kong, W.;Yang, Y.;Zhang, T.;Shi, D.-L.;Zhang, Y.
作者机构:[Kong, W] Institute of Developmental Biology, School of Life Sciences, Shandong University, Shandong Provincial Key Lab. of Animal Cells and Developme 更多
通讯作者:Shi, DL
通讯作者地址:[Shi, DL]Shandong Univ, Inst Dev Biol, Sch Life Sci, Shandong Prov Key Lab Anim Cells & Dev Biol, Jinan 250100, Peoples R China.
来源:Evolution & development
出版年:2012
卷:14
期:2
页码:168-177
DOI:10.1111/j.1525-142X.2012.00533.x
摘要:Wnt signaling plays a key role in embryonic patterning and morphogenetic movements. The secreted Frizzled-related proteins (sFRPs) antagonize Wnt signaling, but their roles in development are poorly understood. To determine whether function of sFRPs is conserved between amphioxus and vertebrates, we characterized sFRP2-like function in the amphioxus, Branchiostoma belcheri tsingtauense (B. belcheri). As in other species of Branchiostome, in B. belcheri, expression of sFRP2-like is restricted to the mesendoderm during gastrulation and to the anterior mesoderm and endoderm during neurulation. Functional analyses in frog (Xenopus laevis) indicate that amphioxus sFRP2-like potently inhibits both canonical and non-canonical Wnts. Thus, sFRP-2 probably functions in amphioxus embryos to inhibit Wnt signaling anteriorly. Moreover, dorsal overexpression of amphioxus sFRP2-like in Xenopus embryos, like inhibition of Wnt11, blocks gastrulation movements. This implies that sFRP2-like may also modulate Wnt signaling during gastrulation movements in amphioxus.
收录类别:SCOPUS;SCIE
WOS核心被引频次:8
Scopus被引频次:7
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863996674&doi=10.1111%2fj.1525-142X.2012.00533.x&partnerID=40&md5=5a0ff694e64ad57671f0eae308b897de
TOP