标题：MAFG-AS1 is a novel clinical biomarker for clinical progression and unfavorable prognosis in gastric cancer
作者：Li, Chao; Wu, Rongfang; Xing, Youzhong
作者机构：[Li, Chao] Shandong Univ Hosp, Dept Lab, Jinan, Shandong, Peoples R China.; [Wu, Rongfang] Taishan Sanat Shandong Prov, Dept Gastroenterol, Tai An, 更多
通讯作者地址：[Xing, YZ]Jinan Cent Hosp, Dept Blood Transfus, Jinan, Shandong, Peoples R China.
关键词：MAFG-AS1; lncRNA; biomarker; gastric cancer
摘要：MAFG antisense 1 (MAFG-AS1) is recently identified as a novel lncRNA and serves as a tumor promoter in several types of human tumor. However, no prior study has been performed to evaluate the role of MAFG-AS1 in gastric cancer. In our study, we found MAFG-AS1 expression was increased in gastric cancer tissue samples compared with normal gastric mucosa tissue samples, and associated with poor overall survival in gastric cancer patients at The Cancer Genome Atlas database. Furthermore, we confirmed the clinical and prognostic significance of MAFG-AS1 in gastric cancer. We found gastric cancer tissues and cell lines had remarkably increased MAFG-AS1 expression in comparison to normal gastric mucosa tissues and normal human gastric epithelial cell line, and high MAFG-AS1 expression was positively associated with diffuse type, advanced clinical stage, extensive depth of invasion, more lymph node metastasis, and present distant metastasis in gastric cancer patients. Moreover, high MAFG-AS1 expression acted as one of the independent poor prognostic factors for overall survival in gastric cancer patients. The loss-of-function study showed knocking down MAFG-AS1 expression inhibited gastric cancer cell proliferation, migration and invasion in vitro. In conclusion, MAFG-AS1 is probable to be a valuable prognostic biomarker, and a novel potential target for gastric cancer.