标题:Iguratimod: a valuable remedy from the Asia Pacific region for ameliorating autoimmune diseases and protecting bone physiology
作者:Li, Jie; Bao, Jun; Zeng, Jian; Yan, Aizhu; Zhao, Chunqiu; Shu, Qiang
作者机构:[Li, Jie; Shu, Qiang] Shandong Univ, Qilu Hosp, Dept Rheumatol, Jinan 250012, Shandong, Peoples R China.; [Bao, Jun; Zeng, Jian; Yan, Aizhu; Zhao, C 更多
通讯作者:Shu, Q;Shu, Q
通讯作者地址:[Shu, Q]Shandong Univ, Qilu Hosp, Dept Rheumatol, Jinan 250012, Shandong, Peoples R China;[Shu, Q]Shandong Univ, Shenzhen Res Inst, Shenzhen 518057, G 更多
来源:BONE RESEARCH
出版年:2019
卷:7
期:1
DOI:10.1038/s41413-019-0067-6
摘要:Autoimmune diseases are affected by complex pathophysiology involving several cell types, cytokines, antibodies, and mimicking factors. Different drugs are used to ameliorate these autoimmune reactions, including nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, antiantibodies, and small molecular drugs (DMARDs), and they are clinically in vogue for diseases such as rheumatoid arthritis (RA). Nevertheless, low cost-effectiveness, reduced efficacy, adverse effects, and patient nonresponse are unappealing factors driving the development of new drugs such as iguratimod. Iguratimod is primarily used to ameliorate RA in Japanese and Chinese clinics. However, its efficacy against other autoimmune ailments is also under intense investigation, and the number of investigations is becoming increasingly larger with each passing day. The articular structure comprises synovium, ligaments, and bone. The latter is more complex than the others since it regulates blood cells and autoimmunity in addition to providing skeletal support to the body. Therefore, its protection is also of prime importance in RA and other autoimmune diseases. Herein, we have highlighted the role of iguratimod in autoimmune diseases and bone protection. We suggest that iguratimod's unique mode of action compared with that of other DMARDs and its good patient response makes it a suitable antirheumatic and bone-protecting drug.
收录类别:SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071742999&doi=10.1038%2fs41413-019-0067-6&partnerID=40&md5=b1a8d3c5b1d837d4a58005eca2a7a52b
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