标题：Lactate: A Novel Signaling Molecule in Synaptic Plasticity and Drug Addiction
作者：Wang, Qiuting; Hu, Ying; Wan, Jiale; Dong, Bo; Sun, Jinhao
作者机构：[Wang, Qiuting; Wan, Jiale; Sun, Jinhao] Shandong Univ, Sch Basic Med, Dept Anat, Key Lab Expt Teratol,Minist Educ, Jinan 250012, Shandong, Peoples R 更多
通讯作者地址：[Sun, JH]Shandong Univ, Sch Basic Med, Dept Anat, Key Lab Expt Teratol,Minist Educ, Jinan 250012, Shandong, Peoples R China.
关键词：drug addiction; energy substrates; lactate; memories; signaling; molecules; synaptic plasticity
摘要：l-Lactate is emerging as a crucial regulatory nexus for energy metabolism in the brain and signaling transduction in synaptic plasticity, memory processes, and drug addiction instead of being merely a waste by-product of anaerobic glycolysis. In this review, the role of lactate in various memory processes, synapse plasticity and drug addiction on the basis of recent studies is summarized and discussed. To this end, three main parts are presented: first, lactate as an energy substrate in energy metabolism of the brain is described; second, lactate as a novel signaling molecule in synaptic plasticity, neural circuits, memory, and drug addiction is described; and third, in light of the above descriptions, it is plausible to speculate that lactate is predominantly a signaling molecule in specific memory processes and partly acts as an energy substrate. The future perspective in lactate signaling involving microglia and associated precise signaling pathways in the brain is highlighted.