标题：Transcranial Magnetic Stimulation in Schizophrenia: The Contribution of Neuroimaging
作者机构：Neurology Department, The 89th Hospital of PLA, Weifang, Shandong, China;Cardiology Department, Qilu Hospital of Shandong Univer
通讯作者地址：[Prakash, R]MS Ramaiah Med Coll & Inst, Dept Physiol, Bangalore, Karnataka, India.
来源：Current topics in medicinal chemistry
关键词：Electro-enchephalogram (eeg);Functional neuro-imaging;Mechanism of action;Repetitive transcranial magnetic stimulation (rtms);Schizophrenia
摘要：At the most basic level, the Transcranial Magnetic Stimulation(TMS) is a neuro-scientific tool that exerts its action by influencing the neo-cortical functions. However, in-spite of so many well-evidenced roles of TMS in neuropsychiatric conditions, its exact mechanism of action remains to be known. More intriguing are its therapeutic effects in Schizophrenia at the Cerebral-level. In this review, we adopt a neuro-imaging approach for this exploration. We review the present literature for the studies in Schizophrenia which have used a combination of rTMS with 1) Electroenchephalogram (EEG) 2)The functional Magnetic Resonance Imaging (fMRI) and the 3) Positron Emission Tomography (PET)/ Single-Photon Emission Computed Tomography. The TMS-EEG combination provides direct effects of TMS on the electro-magnetic field (EMF) of brain. The TMS-fMRI/PET/SPECT combinations are very effective in exploring the functional connectivity in brains of Schizophrenia patients as well as in performing rTMS guided neuro-navigation. Our review suggests that TMS combined with other neuroimaging modalities are needed for a better clarification of its neural actions.