标题：Percutaneous microwave ablation (MWA) increased the serum levels of VEGF and MMP-9 in Stage I non-small cell lung cancer (NSCLC)
作者：Ni, Yang; Ye, Xin; Wan, Chao; Ni, Qing; Yang, Xia; Huang, Guanghui; Li, Wenhong; Wang, Jiao; Han, Xiaoying; Wei, Zhigang; Meng, Mi 更多 作者机构：[Ni, Yang; Ye, Xin; Wan, Chao; Ni, Qing; Yang, Xia; Huang, Guanghui; Li, Wenhong; Wang, Jiao; Han, Xiaoying; Wei, Zhigang; Meng, Min] Shandong Univ, D 更多
通讯作者地址：[Ye, X]Shandong Univ, Dept Oncol, Shandong Prov Hosp, 324 Jingwuweiqi Rd, Jinan 250021, Shandong, Peoples R China.
来源：INTERNATIONAL JOURNAL OF HYPERTHERMIA
关键词：Microwave ablation (MWA); VEGF; MMP-9; non-small cell lung cancer; (NSCLC)
摘要：Background: Lung cancer is the leading cause of cancer death around the world. Percutaneous microwave ablation (MWA) is an emerging treatment strategy for medically inoperable early-stage non-small cell lung cancer (NSCLC). In this study, we investigated the association of MWA and serum angiogensis promoters VEGF and MMP-9 in these patients subgroup.Methods: We enrolled 52 patients with Stage I NSCLC patients in this study. For each patient, blood samples were drawn by venous puncture, one immediately prior to MWA and the others on Post-Procedure Days (PPD) 1, 3, 5, 7, 10 and 14. Serum samples were analysed for VEGF and MMP-9 levels with use of commercially available enzyme-linked immunosorbent assay. Also, blood samples of 28 healthy volunteers were set as the healthy controls.Results: We did not observe a significant difference of serum VEGF and MMP-9 between NSCLC patients and healthy controls. The VEGF levels increased on the first day (256.06.16pg/ml, p<0.05) after MWA and peaked on the PPD3 (418.0 +/- 14.54pg/ml, p<0.05). Although it gradually reduced afterwards, its levels on PPD14 (141.2 +/- 4.41pg/ml, p<0.05) was still higher than pre-procedure level. The serum MMP-9 level was significantly elevated from PPD1 (231.3 +/- 7.93ng/ml, p<0.05) until PPD10 (155.3 +/- 5.62ng/ml, p<0.05), while it normalised to pre-procedure level on PPD14 (90.78 +/- 3.36ng/ml, p>0.05). The highest MMP-9 level was observed on PPD5 (399.7 +/- 17.70ng/ml, p<0.05).Conclusion: Our preliminary results indicated that percutaneous MWA resulted in increased serum levels of VEGF and MMP-9 in Stage I NSCLC patients. Antiangiogenesis approaches may be helpful for patients defending against metastases during the immediate post-ablation time window.