标题:Percutaneous microwave ablation (MWA) increased the serum levels of VEGF and MMP-9 in Stage I non-small cell lung cancer (NSCLC)
作者:Ni, Yang; Ye, Xin; Wan, Chao; Ni, Qing; Yang, Xia; Huang, Guanghui; Li, Wenhong; Wang, Jiao; Han, Xiaoying; Wei, Zhigang; Meng, Mi 更多
作者机构:[Ni, Yang; Ye, Xin; Wan, Chao; Ni, Qing; Yang, Xia; Huang, Guanghui; Li, Wenhong; Wang, Jiao; Han, Xiaoying; Wei, Zhigang; Meng, Min] Shandong Univ, D 更多
通讯作者:Ye, X
通讯作者地址:[Ye, X]Shandong Univ, Dept Oncol, Shandong Prov Hosp, 324 Jingwuweiqi Rd, Jinan 250021, Shandong, Peoples R China.
来源:INTERNATIONAL JOURNAL OF HYPERTHERMIA
出版年:2017
卷:33
期:4
页码:435-439
DOI:10.1080/02656736.2017.1284350
关键词:Microwave ablation (MWA); VEGF; MMP-9; non-small cell lung cancer; (NSCLC)
摘要:Background: Lung cancer is the leading cause of cancer death around the world. Percutaneous microwave ablation (MWA) is an emerging treatment strategy for medically inoperable early-stage non-small cell lung cancer (NSCLC). In this study, we investigated the association of MWA and serum angiogensis promoters VEGF and MMP-9 in these patients subgroup.Methods: We enrolled 52 patients with Stage I NSCLC patients in this study. For each patient, blood samples were drawn by venous puncture, one immediately prior to MWA and the others on Post-Procedure Days (PPD) 1, 3, 5, 7, 10 and 14. Serum samples were analysed for VEGF and MMP-9 levels with use of commercially available enzyme-linked immunosorbent assay. Also, blood samples of 28 healthy volunteers were set as the healthy controls.Results: We did not observe a significant difference of serum VEGF and MMP-9 between NSCLC patients and healthy controls. The VEGF levels increased on the first day (256.06.16pg/ml, p<0.05) after MWA and peaked on the PPD3 (418.0 +/- 14.54pg/ml, p<0.05). Although it gradually reduced afterwards, its levels on PPD14 (141.2 +/- 4.41pg/ml, p<0.05) was still higher than pre-procedure level. The serum MMP-9 level was significantly elevated from PPD1 (231.3 +/- 7.93ng/ml, p<0.05) until PPD10 (155.3 +/- 5.62ng/ml, p<0.05), while it normalised to pre-procedure level on PPD14 (90.78 +/- 3.36ng/ml, p>0.05). The highest MMP-9 level was observed on PPD5 (399.7 +/- 17.70ng/ml, p<0.05).Conclusion: Our preliminary results indicated that percutaneous MWA resulted in increased serum levels of VEGF and MMP-9 in Stage I NSCLC patients. Antiangiogenesis approaches may be helpful for patients defending against metastases during the immediate post-ablation time window.
收录类别:SCOPUS;SCIE
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011556749&doi=10.1080%2f02656736.2017.1284350&partnerID=40&md5=cb82d56868016af519b44e80f6bfa478
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