标题：Prognosis and clinicopathology of CXCR4 in colorectal cancer patients: A meta-analysis
作者：Li L.-N.; Jiang K.-T.; Tan P.; Wang A.-H.; Kong Q.-Y.; Wang C.-Y.; Lu H.-R.; Wang J.
作者机构：[Li, L.-N] Department of Gastroenterology, Linyi People's Hospital, Linyi, China;[ Jiang, K.-T] Department of Gastroenterology, Linyi People's Hospita 更多
通讯作者地址：Wang, J.; Department of Hepatology, Provincial Hospital Affiliated to Shandong UniversityChina
来源：Asian Pacific Journal of Cancer Prevention
关键词：Clinicopathology; Colorectal cancer; CXCR4; Prognosis
摘要：The chemokine receptor 4 (CXCR4) has been widely used in diagnosis and prognosis of colorectal cancer (CRC). However, there is no current consensus on the impact of CXCR4 on CRC patients. The purpose of this study was to evaluate the prognostic and clinicopathological importance of CXCR4 in CRC patients. Databases, such as PubMed, Cochrane library, CBM and EMBASE updated to 2014 were searched to include eligible articles. We analysed correlations between CXCR4 expression and clinicopathological features and overall survival (OS). A total of 1, 055 CRC patients from twelve studies were included in the study. The pooled odds ratios (ORs) which indicated CXCR4 expression was likely to be associated with TNM stage (OR=0.43, CI=0.34-0.55, P<0.00001), lymph node status (OR=2.23, CI=1.23-4.05, P=0.008) and vascular invasion (OR=2.21, CI=1.11-4.39, P=0.02). Poor overall survival of CRC cancer was found to be significantly related to CXCR4 overexpression (hazard ratio (HR) 1.36 CI=1.17-1.59, P<0.0001), whereas combined ORs revealed that CXCR4 expression had no correlation with gender or differentiation. Based on the published studies, CXCR4 overexpression in patients w ith CRC indicates poor survival outcome and clinicopathological factors.