标题：Downregulation of GRIM-19 promotes growth and migration of human glioma cells
作者：Zhang, Yanmin; Hao, Hongbo; Zhao, Shidou; Liu, Qian; Yuan, Qiuhuan; Ni, Shilei; Wang, Fuwu; Liu, Shangming; Wang, Liyan; Hao, Aijun
作者机构：[Zhang, Yanmin; Zhao, Shidou; Liu, Qian; Yuan, Qiuhuan; Wang, Fuwu; Liu, Shangming; Wang, Liyan; Hao, Aijun] Shandong Univ, Sch Med, Dept Histol & Emb 更多
通讯作者地址：[Hao, AJ]Shandong Univ, Sch Med, Dept Histol & Embryol, Key Lab,Minist Educ Expt Teratol, Jinan 250100, Peoples R China.
摘要：It has become increasingly clear that there are notable parallels between normal development and tumorigenesis. Glioma is a classic model that links between tumorigenesis and development. We evaluated the expression of GRIM-19, a novel gene essential for normal development, in various grades of gliomas and several human glioma cell lines. We showed that GRIM-19 mRNA and protein expression were markedly lower in gliomas than in control brain tissues and negatively correlated with the malignancy of gliomas. Downregulation of GRIM-19 in glioma cells significantly enhanced cell proliferation and migration, whereas overexpression of GRIM-19 showed the opposite effects. We also showed that the activation of signal transducer and activator of transcription 3 (STAT3) and the expression of many STAT3-dependent genes were regulated by the expression of GRIM-19. In addition, GRIM-19 exerted its role probably through the non-STAT3 signaling pathway. Collectively, our data suggest that most gliomas expressed GRIM-19 at low levels, which may play a major role in tumorigenesis in the brain. (Cancer Sci 2011; 102: 1991-1999)