标题：Review: Recent application of chiral liquid chromatography-tandem mass spectrometric methods for enantiomeric pharmaceutical and biomedical determinations
作者：Nie, Y.;Liu, X.;Yang, X.;Zhao, Z.
作者机构：[Nie, Y] School of Pharmaceutical Sciences, Center for Pharmaceutical Research and Drug Delivery Systems, Shandong University, Jinan, Shandong 250012, 更多
通讯作者地址：[Zhao, ZX]Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China.
来源：Journal of Chromatographic Science
摘要：The technology of analyzing the pharmacological and toxicological properties of chiral drugs has become more commonly utilized since the knowledge of the biological actions of enantiomers has been gradually acquired during the last few decades. This work reviews the applications of chiral liquid chromatography coupled to tandem mass spectrometry (LC-MS) for the analysis of chiral pharmaceuticals since 2005. The enantioselective determinations in pharmaceutical and biomedical fields with LC-MS are classified based on three mobile phase modes, including normal phase, reversed phase and polar organic solvent, in terms of their compatibility with various ionization sources and specific applications.