标题:Neuropeptides Exert Neuroprotective Effects in Alzheimer's Disease
作者:Chen, Xin-Yi; Du, Yi-Feng; Chen, Lei
作者机构:[Chen, Xin-Yi; Chen, Lei] Qingdao Univ, Dept Physiol & Pathophysiol, Qingdao, Peoples R China.; [Chen, Xin-Yi; Du, Yi-Feng] Shandong Univ, Dept Neur 更多
通讯作者:Chen, L
通讯作者地址:[Chen, L]Qingdao Univ, Dept Physiol & Pathophysiol, Qingdao, Peoples R China.
来源:FRONTIERS IN MOLECULAR NEUROSCIENCE
出版年:2019
卷:11
DOI:10.3389/fnmol.2018.00493
关键词:neuropeptide; Alzheimer's disease; ghrelin; neurotensin; pituitary; adenylate cyclase-activating polypeptide; neuropeptide Y; substance P;; orexin
摘要:Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by cognitive deficits and neuronal loss. Deposition of beta-amyloid peptide (A beta) causes neurotoxicity through the formation of plaques in brains of Alzheimer's disease. Numerous studies have indicated that the neuropeptides including ghrelin, neurotensin, pituitary adenylate cyclase-activating polypeptide (PACAP), neuropeptide Y, substance P and orexin are closely related to the pathophysiology of Alzheimer's disease. The levels of neuropeptides and their receptors change in Alzheimer's disease. These neuropeptides exert neuroprotective roles mainly through preventing A beta accumulation, increasing neuronal glucose transport, increasing the production of neurotrophins, inhibiting endoplasmic reticulum stress and autophagy, modulating potassium channel activity and hippocampal long-term potentiation. Therefore, the neuropeptides may function as potential drug targets in the prevention and cure of Alzheimer's disease.
收录类别:SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064192023&doi=10.3389%2ffnmol.2018.00493&partnerID=40&md5=1cfbc01f58169af1d6c5109d60200f11
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