标题：Neuropeptides Exert Neuroprotective Effects in Alzheimer's Disease
作者：Chen, Xin-Yi; Du, Yi-Feng; Chen, Lei
作者机构：[Chen, Xin-Yi; Chen, Lei] Qingdao Univ, Dept Physiol & Pathophysiol, Qingdao, Peoples R China.; [Chen, Xin-Yi; Du, Yi-Feng] Shandong Univ, Dept Neur 更多
通讯作者地址：[Chen, L]Qingdao Univ, Dept Physiol & Pathophysiol, Qingdao, Peoples R China.
来源：FRONTIERS IN MOLECULAR NEUROSCIENCE
关键词：neuropeptide; Alzheimer's disease; ghrelin; neurotensin; pituitary; adenylate cyclase-activating polypeptide; neuropeptide Y; substance P;; orexin
摘要：Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by cognitive deficits and neuronal loss. Deposition of beta-amyloid peptide (A beta) causes neurotoxicity through the formation of plaques in brains of Alzheimer's disease. Numerous studies have indicated that the neuropeptides including ghrelin, neurotensin, pituitary adenylate cyclase-activating polypeptide (PACAP), neuropeptide Y, substance P and orexin are closely related to the pathophysiology of Alzheimer's disease. The levels of neuropeptides and their receptors change in Alzheimer's disease. These neuropeptides exert neuroprotective roles mainly through preventing A beta accumulation, increasing neuronal glucose transport, increasing the production of neurotrophins, inhibiting endoplasmic reticulum stress and autophagy, modulating potassium channel activity and hippocampal long-term potentiation. Therefore, the neuropeptides may function as potential drug targets in the prevention and cure of Alzheimer's disease.