标题：Long noncoding RNA LINC-PINT is inhibited in gastric cancer and predicts poor survival
作者：Feng, Hua; Zhang, Junyong; Shi, Yongjun; Wang, Lifen; Zhang, Chunqing; Wu, Lei
作者机构：[Feng, Hua; Zhang, Junyong; Shi, Yongjun; Wang, Lifen; Zhang, Chunqing; Wu, Lei] Shandong Univ, Dept Digest Dis, Shandong Prov Hosp, 324 Five Weft Sev 更多
通讯作者地址：[Wu, L]Shandong Univ, Dept Digest Dis, Shandong Prov Hosp, 324 Five Weft Seven Rd, Jinan 250021, Shandong, Peoples R China.
来源：JOURNAL OF CELLULAR BIOCHEMISTRY
关键词：cancer; gastric cancer; lncRNA LINC-PINT; miR-21; prognosis
摘要：Long noncoding RNA (lncRNA) LINC-PINT expression is inhibited in many types of cancer cells, suggesting its role as a tumor suppressor. However, the functionality of LINC-PINT in gastric cancer and the clinical values are unknown. In the present study, we found that lncRNA LINC-PINT was downregulated, while microRNA-21 (miR-21) was upregulated in tumor tissues than in adjacent healthy tissues of gastric cancer patients. A significant and inverse correlation between expression levels of lncRNA LINC-PINT and miR-21 was found in both tumor tissues and adjacent healthy tissues. The low expression level of LINC-PINT and high expression level of the miR-21 tumor were correlated with poor prognosis. LINC-PINT overexpression casued miR-21 inhibition in cells of human gastric cancer cell lines, while miR-21 overexpression did not alter LINC-PINT expression. LINC-PINT overexpression led to inhibited, while miR-21 overexpression led to promoted proliferation, migration, and invasion of gastric cancer cells. Effects of LINC-PINT overexpression on cellular behaviors of gastric cancer cells were attenuated by miR-21 overexpression. Therefore, LINC-PINT may participate in gastric cancer through the crosstalk with miR-21.