标题:Long noncoding RNA LINC-PINT is inhibited in gastric cancer and predicts poor survival
作者:Feng, Hua; Zhang, Junyong; Shi, Yongjun; Wang, Lifen; Zhang, Chunqing; Wu, Lei
作者机构:[Feng, Hua; Zhang, Junyong; Shi, Yongjun; Wang, Lifen; Zhang, Chunqing; Wu, Lei] Shandong Univ, Dept Digest Dis, Shandong Prov Hosp, 324 Five Weft Sev 更多
通讯作者:Wu, L
通讯作者地址:[Wu, L]Shandong Univ, Dept Digest Dis, Shandong Prov Hosp, 324 Five Weft Seven Rd, Jinan 250021, Shandong, Peoples R China.
来源:JOURNAL OF CELLULAR BIOCHEMISTRY
出版年:2019
卷:120
期:6
页码:9594-9600
DOI:10.1002/jcb.28236
关键词:cancer; gastric cancer; lncRNA LINC-PINT; miR-21; prognosis
摘要:Long noncoding RNA (lncRNA) LINC-PINT expression is inhibited in many types of cancer cells, suggesting its role as a tumor suppressor. However, the functionality of LINC-PINT in gastric cancer and the clinical values are unknown. In the present study, we found that lncRNA LINC-PINT was downregulated, while microRNA-21 (miR-21) was upregulated in tumor tissues than in adjacent healthy tissues of gastric cancer patients. A significant and inverse correlation between expression levels of lncRNA LINC-PINT and miR-21 was found in both tumor tissues and adjacent healthy tissues. The low expression level of LINC-PINT and high expression level of the miR-21 tumor were correlated with poor prognosis. LINC-PINT overexpression casued miR-21 inhibition in cells of human gastric cancer cell lines, while miR-21 overexpression did not alter LINC-PINT expression. LINC-PINT overexpression led to inhibited, while miR-21 overexpression led to promoted proliferation, migration, and invasion of gastric cancer cells. Effects of LINC-PINT overexpression on cellular behaviors of gastric cancer cells were attenuated by miR-21 overexpression. Therefore, LINC-PINT may participate in gastric cancer through the crosstalk with miR-21.
收录类别:SCIE
资源类型:期刊论文
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