标题： Induced Pluripotent Stem Cells and Periodontal Regeneration.
作者： Du, Mi; Duan, Xuejing; Yang, Pishan
作者机构：[ Du, Mi; Du M] Shandong provincial key laboratory of oral tissue regeneration, Department of Periodontology, School of Stomatology, Shandong Universi 更多
来源： Current oral health reports
摘要： Periodontitis is a chronic inflammatory disease which leads to destruction of both the soft and hard tissues of the periodontium. Tissue engineering is a therapeutic approach in regenerative medicine that aims to induce new functional tissue regeneration via the synergistic combination of cells, biomaterials, and/or growth factors. Advances in our understanding of the biology of stem cells, including embryonic stem cells and mesenchymal stem cells, have provided opportunities for periodontal tissue engineering. However, there remain a number of limitations affecting their therapeutic efficiency. Due to the considerable proliferation and differentiation capacities, recently described induced pluripotent stem cells (iPSCs) provide a new way for cell-based therapies for periodontal regeneration. This review outlines the latest status of periodontal tissue engineering and highlights the potential use of iPSCs in periodontal tissue regeneration.