标题:Design, Synthesis, and Structure-Activity Relationship of Novel Indole Derivatives as Potent Akt Inhibitors
作者:Yang,Dezhi;Wang,Peng;Zhao,Guisen;
作者机构:[Yang,Dezhi;Wang,Peng;Zhao,Guisen]Department of Medicinal Chemistry,Key Laboratory of Chemical Biology(Ministry of Education),School of Pharmaceutical 更多
会议名称:中国化学会第八届有机化学学术会议暨首届重庆有机化学国际研讨会
来源:中国化学会第八届有机化学学术会议暨首届重庆有机化学国际研讨会论文摘要集(5)
出版年:2013
关键词:indole;structure-activity relationship;anticancer
摘要:A new series of 1,2,4,7-tetra-substituted indole derivatives were designed and synthesized by modification of a weak hit methyl-4-(2-aminoethoxy)-1H-indole-2-carboxylate with inhibitory rate 48.6% against Akt1 and their antiproliferation on PC-3 cell and Akt1 inhibitory activity were evaluated. Our ...
资源类型:会议论文
原文链接:http://kns.cnki.net/kns/detail/detail.aspx?FileName=ZGHY201310025521&DbName=IPFD2015
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