标题:Enzymatic synthesis of human blood group P1 pentasaccharide antigen
作者:Tsering, Dawa; Chen, Congcong; Ye, Jinfeng; Han, Zhipeng; Jing, Bai-qian; Liu, Xian-wei; Chen, Xi; Wang, Fengshan; Ling, Peixue; Cao 更多
作者机构:[Tsering, Dawa; Chen, Congcong; Ye, Jinfeng; Han, Zhipeng; Liu, Xian-wei; Wang, Fengshan; Ling, Peixue; Cao, Hongzhi] Shandong Univ, Natl Glycoengn Re 更多
通讯作者:Cao, Hongzhi
通讯作者地址:[Cao, HZ]Shandong Univ, Natl Glycoengn Res Ctr, Shandong Prov Key Lab Carbohydrate Chem & Glycobi, Jinan 250012, Peoples R China;[Cao, HZ]Shandong Uni 更多
来源:CARBOHYDRATE RESEARCH
出版年:2017
卷:438
页码:39-43
DOI:10.1016/j.carres.2016.11.019
关键词:P1 antigen; Human blood group; Glycosylation; One-pot multienzyme;; Glycosyltransferase
摘要:The enzymatic synthesis of biologically important and structurally unique human P1PK blood group type P1 pentasaccharide antigen is described. This synthesis features a three-step sequential one-pot multi enzyme (OPME) glycosylation for the stepwise enzymatic chain elongation of readily available lactoside acceptor with cheap and commercially available galactose and N-acetylglucosamine as donor precursors. This enzymatic synthesis provides an operationally simple approach to access P1 pentasaccharide and its structurally related Gb3 and P1 trisaccharide epitopes. (C) 2016 Elsevier Ltd. All rights reserved.
收录类别:EI;SCOPUS;SCIE
WOS核心被引频次:2
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85003741922&doi=10.1016%2fj.carres.2016.11.019&partnerID=40&md5=ad9f8dad3ab33d9192021344eb9a3385
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