标题:Tumor resident mesenchymal stromal cells endow naive stromal cells with tumor-promoting properties
作者:Ren, G.; Liu, Y.; Zhao, X.; Zhang, J.; Zheng, B.; Yuan, Z-R; Zhang, L.; Qu, X.; Tischfield, J. A.; Shao, C.; Shi, Y.
作者机构:[Ren, G.; Zhang, J.; Yuan, Z-R; Zhang, L.; Shi, Y.] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Rutgers Biomed & Hlth Sci, Child Hlth Ins 更多
通讯作者:Shao, C
通讯作者地址:[Shao, C]Rutgers State Univ, Dept Genet, Piscataway, NJ 08854 USA.
来源:ONCOGENE
出版年:2014
卷:33
期:30
页码:4016-4020
DOI:10.1038/onc.2013.387
关键词:mesenchymal stem/stromal cells; lymphoma; tumor promotion; tumor; microenvironment; chemokines; macrophages
摘要:Bone marrow mesenchymal stem/stromal cells (BM-MSCs) can infiltrate into tumors and subsequently evolve into tumor resident MSCs in tumor microenvironment. In this study, using a mouse lymphoma model, we showed that the lymphoma resident MSCs (L-MSCs) are able to confer tumor-promoting property to the naive cocultured BM-MSCs. Examination of cytokines and chemokines showed that post exposure to L-MSCs, BM-MSCs acquired an expression profile that is similar to that in L-MSCs. In vivo, BM-MSCs educated by L-MSCs (BM-L-MSCs) possess a greatly enhanced ability in promoting lymphoma growth. Consistent with an elevated CCL-2 expression in BM-L-MSCs, the tumor-promoting effect of BM-L-MSCs largely depends on CCR2-mediated macrophage recruitment to tumor sites. We further showed that the transmission of tumor-promoting effect is partially mediated by soluble factors. Our findings thus revealed a novel reinforcing mechanism in the maintenance of tumor microenvironment.
收录类别:SCOPUS;SCIE
WOS核心被引频次:13
Scopus被引频次:13
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905033775&doi=10.1038%2fonc.2013.387&partnerID=40&md5=0bdf9058dda4175d2de44398a694f12f
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