标题：Tumor resident mesenchymal stromal cells endow naive stromal cells with tumor-promoting properties
作者：Ren, G.; Liu, Y.; Zhao, X.; Zhang, J.; Zheng, B.; Yuan, Z-R; Zhang, L.; Qu, X.; Tischfield, J. A.; Shao, C.; Shi, Y.
作者机构：[Ren, G.; Zhang, J.; Yuan, Z-R; Zhang, L.; Shi, Y.] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Rutgers Biomed & Hlth Sci, Child Hlth Ins 更多
通讯作者地址：[Shao, C]Rutgers State Univ, Dept Genet, Piscataway, NJ 08854 USA.
关键词：mesenchymal stem/stromal cells; lymphoma; tumor promotion; tumor; microenvironment; chemokines; macrophages
摘要：Bone marrow mesenchymal stem/stromal cells (BM-MSCs) can infiltrate into tumors and subsequently evolve into tumor resident MSCs in tumor microenvironment. In this study, using a mouse lymphoma model, we showed that the lymphoma resident MSCs (L-MSCs) are able to confer tumor-promoting property to the naive cocultured BM-MSCs. Examination of cytokines and chemokines showed that post exposure to L-MSCs, BM-MSCs acquired an expression profile that is similar to that in L-MSCs. In vivo, BM-MSCs educated by L-MSCs (BM-L-MSCs) possess a greatly enhanced ability in promoting lymphoma growth. Consistent with an elevated CCL-2 expression in BM-L-MSCs, the tumor-promoting effect of BM-L-MSCs largely depends on CCR2-mediated macrophage recruitment to tumor sites. We further showed that the transmission of tumor-promoting effect is partially mediated by soluble factors. Our findings thus revealed a novel reinforcing mechanism in the maintenance of tumor microenvironment.