标题：NT-proBNP plays an important role in the effect of ibuprofen on preterm infants with patent ductus arteriosus
作者：Ding, Y. -J.; Han, B.; Yang, B.; Zhu, M.
作者机构：[Ding, Y. -J.; Han, B.; Yang, B.; Zhu, M.] Shandong Univ, Prov Hosp, Jinan 250100, Peoples R China.; [Ding, Y. -J.] Yantai Yuhuangding Hosp, Yantai, 更多
通讯作者地址：[Han, B]Shandong Univ, Prov Hosp, Jinan 250100, Peoples R China.
来源：EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
关键词：N-terminal pro-brain natriuretic peptide (NT-proBNP); Ibuprofen; Patent; ductus arteriosus (PDA)
摘要：OBJECTIVE: The aim of this study was to clarify the role of N-terminal probrain natriuretic peptide, (NT-proBNP) in ibuprofen on preterm infants with patent ductus arteriosus (PDA).; PATIENTS AND METHODS: Preterm infants with PDA were enrolled in the present study. Patients were randomized into two groups: ibuprofen group received oral ibuprofen 10 mg/kg, followed by 5 mg/kg after 24 and 48 h, and the placebo group received the same volume of 5% glucose. PDA and NT-proBNP were detected during 24 hours, 3 and 7 days of age.; RESULTS: The results indicated that babies who received oral ibuprofen had higher PDA closure at 7 days after treatment (p < 0.05). Significantly decrease of NT-proBNP was found in ibuprofen group than the placebo group at 3 and 7 days (all p < 0.05).; CONCLUSIONS: Collectively, the favorable effects of ibuprofen on PDA in premature infants maybe mediated in part by the reduction of NT-proBNP level.