标题:Recent Advances in the Discovery of PqsD Inhibitors as Antimicrobial Agents
作者:Zhou, Ziteng; Ma, Shutao
作者机构:[Zhou, Ziteng; Ma, Shutao] Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Key Lab Chem Biol,Minist Educ, 44 West Culture Rd, Jinan 250012, Peoples 更多
通讯作者:Ma, ST
通讯作者地址:[Ma, ST]Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Key Lab Chem Biol,Minist Educ, 44 West Culture Rd, Jinan 250012, Peoples R China.
来源:CHEMMEDCHEM
出版年:2017
卷:12
期:6
页码:420-425
DOI:10.1002/cmdc.201700015
关键词:antimicrobial agents; inhibitors; PqsD; quinolone signal; quorum sensing
摘要:The treatment of the infections caused by Pseudomonas aeruginosa, an opportunistic Gram-negative bacterium, is very difficult. High intrinsic tolerance toward common antibiotics and the development of new resistant strains challenge us to find a new treatment as soon as possible. PqsD is an enzyme essential for the P.aeruginosa quorum-sensing apparatus, which catalyzes the final and key step in the biosynthesis of 4-hydroxy-2-heptylquinolone (HHQ), which is a signal molecule of the P.aeruginosa quorum-sensing system. In this review, following an outline on their structures, we present a brief introduction of the PqsD inhibitors including their mechanisms of action, inhibitory activity, and structure-activity relationships.
收录类别:SCOPUS;SCIE
WOS核心被引频次:2
Scopus被引频次:1
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014556547&doi=10.1002%2fcmdc.201700015&partnerID=40&md5=c6849980f33b810c4e5dfab0f35bf824
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