标题：Effects of Nanotoxicity on Female Reproductivity and Fetal Development in Animal Models
作者：Sun, Jianling; Zhang, Qiu; Wang, Zhiping; Yan, Bing
作者机构：[Sun, Jianling; Zhang, Qiu; Yan, Bing] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China.; [Wang, Zhiping] Shandong Univ, Sch Publ 更多
通讯作者地址：[Yan, B]Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China.
来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
关键词：nanotoxicity; reproductivity; development; animal model; zebrafish
摘要：The extensive application of nanomaterials in industry, medicine and consumer products has raised concerns about their potential toxicity. The female population is particularly vulnerable and deserves special attention because toxicity in this group may impact both female reproductivity and fetal development. Mouse and zebrafish models each have their own unique features and studies using these models to examine the potential toxicity of various nanoparticles are compared and summarized in this review. Several nanoparticles exhibit detrimental effects on female reproductivity as well as fetal development, and these adverse effects are related to nanoparticle composition, surface modification, dose, exposure route and animal species. Limited studies on the mechanisms of nanotoxicity are also documented and reviewed herein.