标题:Novel supramolecular organogel based on beta-cyclodextrin as a green drug carrier for enhancing anticancer effects
作者:Li, Zhaolou; Zhang, Bo; Jia, Shaohui; Ma, Mingfang; Hao, Jingcheng
作者机构:[Li, Zhaolou; Zhang, Bo; Jia, Shaohui; Ma, Mingfang] Jining Med Univ, Coll Basic Med, Jining 272067, Peoples R China.; [Hao, Jingcheng] Shandong Uni 更多
通讯作者:Li, ZL
通讯作者地址:[Li, ZL]Jining Med Univ, Coll Basic Med, Jining 272067, Peoples R China.
来源:JOURNAL OF MOLECULAR LIQUIDS
出版年:2018
卷:250
页码:19-25
DOI:10.1016/j.molliq.2017.11.154
关键词:Supramolecular organogel; beta-Cyclodextrin; Glycerol; Drug carrier;; Hydrogen-bonded network
摘要:Two -component gel of beta-cyclodextrin as gelator and glycerol as solvent is investigated. This novel gel loading with 5-fluorouracil or methotrexate can enhance anticancer abilities effectively. So, the blank beta-cyclodextrin-cyclodextrin gel can be a candidate for versatile drug delivery. The morphology of the gel is characterized by OM and SEM. The rheology and DSC are also applied to study the properties of the obtained gel. The mechanism of gel formation is analyzed by FT-IR and XRD, indicating the main driving forces for gel formation are self-aggregation of pcyclodextrins and H-bondings between glycerol molecules. Amazingly, an in vitro cytotoxicity assay on human hepatocellular carcinoma cells lines shows that the drug-loaded gels with 5-fluorouracil or methotrexate exhibit better anti-cancer effects than that of those two drugs. Hence, the present work developed a new and low-cost drug carrier, which has potential application in drug delivery. (C) 2017 Elsevier B.V. All rights reserved.
收录类别:SCIE
WOS核心被引频次:2
资源类型:期刊论文
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