标题：25-Hydroxyvitamin D is closely related with the function of the pancreatic islet beta cells
作者：Guo, Jingjing; Xiao, Zhengda; Xue, Xia; Liu, Xin; Lu, Yong; Yin, Xiao; Ma, Kun
作者机构：[Guo, Jingjing] Beijing Univ Chinese Med, Sch Med, Beijing 100029, Peoples R China.; [Xiao, Zhengda; Xue, Xia; Liu, Xin] Beijing Univ Chinese Med, B 更多
通讯作者地址：[Xiao, ZD]Beijing Univ Chinese Med, Beijing 100029, Peoples R China.
来源：PAKISTAN JOURNAL OF MEDICAL SCIENCES
关键词：Vitamin D; Diabetes mellius; Type 2; Pancreatic islet beta cell
摘要：Objectives: This study is to investigate the relationship between 25-Hydroxyvitamin D (25-OH-D) and pancreatic islet beta cell function under different glucose tolerance statuses in China.; Methodology: Totally, 180 patients with type 2 diabetes mellitus (DM group), 178 patients with impaired fasting glucose/impaired glucose tolerance (IFG/IGT group), and 160 normal control subjects (NGT group) were included to measure their body parameters and biochemical parameters. In oral glucose tolerance test, fasting serum 25-OH-D was assessed by the enzyme-linked immunosorbent assay (ELISA). Homeostasis model assessment for insulin resistance (Homa-IR), insulin acuity index (IAI), beta-cell function index (Homa-BCF) as well as secretion index (IS) were determined.; Results: The levels of 25-OH-D, IAI and Homa-BCF in the DM group and IFG/IGT group were significantly lower than that in NGT group (P < 0.05). Homa-IR in DM group and IFG/IGT group was significantly higher than that in the NGT group (P < 0.05). Pearson correlation analysis and partial correlation analysis showed that 25-OH-D was positively correlated with fasting insulin (FINS) and Homa-BCF (P < 0.05). Multiple stepwise regression analysis showed that 25-OH-D was one of the influential factors of pancreatic islet beta cell function in patients with type 2 diabetes mellitus.; Conclusions: Our results suggest that 25-OH-D is closely related with the function of the pancreatic islet beta cells and is one of the influential factors of pancreatic islet beta cell function.