标题：Childhood body mass index and blood pressure in prediction of subclinical vascular damage in adulthood: Beijing blood pressure cohort
作者机构：[Yan, Y] Department of Epidemiology, Capital Institute of Pediatrics, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China, Graduate School of 更多
通讯作者地址：[Mi, J]Capital Inst Pediat, Dept Epidemiol, 2 Yabao Rd, Beijing 100020, Peoples R China.
来源：Journal of Hypertension
关键词：arterial stiffness; atherosclerosis; blood pressure; BMI; childhood
摘要：OBJECTIVE:: Atherosclerosis and arterial stiffness predict cardiovascular morbidity and mortality. We aimed to investigate the influence of BMI and blood pressure (BP) in childhood, and change in BMI and BP, on the development of subclinical atherosclerosis and arterial stiffness in adulthood.
METHODS:: The study consisted of 1252 individuals aged 27–42 years who had 2–10 measurements of BMI and BP from childhood. In the final survey (2010–2011), subclinical markers of vascular damage, including carotid intima–media thickness (cIMT), carotid-femoral pulse wave velocity (cfPWV), and brachial-ankle pulse wave velocity (baPWV), were measured.
RESULTS:: Pearson correlation analyses showed that BMI and BP in childhood and adulthood, and also cumulative and incremental values from childhood to adulthood, were all significantly associated with adult cIMT, cfPWV, and baPWV in males and in females (all P