标题：Hemodynamic responses to magnetic stimulation of carotid sinus in normotensive rabbits
作者机构：[Zhang, J] Department of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, Jiangsu, 210002, China, 更多
通讯作者地址：[Xu, GL]Nanjing Univ, Jinling Hosp, Dept Neurol, Med Sch, 305 East Zhongshan Rd, Nanjing 210002, Jiangsu, Peoples R China.
来源：Journal of Hypertension
关键词：arterial pressure; carotid baroreflex; hypertension; magnetic; stimulation; sinoaortic denervation
摘要：OBJECTIVES:: Carotid baroreflex plays a crucial role in regulating arterial pressure. Based on this knowledge, electrical stimulation of carotid sinus was designed for treating resistant hypertension. However, the clinical implication of electrical stimulation of carotid sinus is largely restrained due to obvious invasiveness. This study aimed to evaluate the efficacy of magnetic stimulation of carotid sinus (MSCS), a noninvasive strategy, for lowering blood pressure in rabbits.
METHODS:: MSCS with graded intensities and frequencies were systematically attempted in normotensive rabbits. Blood pressure was recorded dynamically. Sinoaortic denervation and plasma hormone level analyses were performed.
RESULTS:: When the right carotid sinus was stimulated at 1 Hz frequency, a dose–effect relationship was observed between stimulation intensity (100–250% motor threshold) and mean arterial pressure (MAP) decrement (3.6 ± 1.0 to 10.4 ± 2.3 mmHg). When stimulation intensity was fixed at 200% motor threshold, the median reduction of MAP in 1-Hz group [10.8 (8.6–14.9) mmHg] was significantly higher than that in other frequency groups (all P