标题：Effect of ZrO2additions on the crystallization, mechanical and biological properties of MgO-CaO-SiO2-P2O5-CaF2bioactive glass-ceramics
作者：Li, H.C. ;Wang, D.G. ;Meng, X.G. ;Chen, C.Z.
作者机构：[Li, H.C. ;Wang, D.G. ;Meng, X.G. ;Chen, C.Z. ] Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Educatio 更多
来源：Colloids and Surfaces B: Biointerfaces
摘要：A series of ZrO2doped MgO-CaO-SiO2-P2O5-CaF2bioactive glass-ceramics were obtained by sintering method. The crystallization behavior, phase composition, morphology and structure of glass-ceramics were characterized. The bending strength, elastic modulus, fracture toughness, micro-hardness and thermal expansion coefficient (TEC) of glass-ceramics were investigated. The in vitro bioactivity and cytotoxicity tests were used to evaluate the bioactivity and biocompatibility of glass-ceramics. The sedimentation mechanism and growth process of apatites on sample surface were discussed. The results showed that the mainly crystalline phases of glass-ceramics were Ca5(PO4)3F (fluorapatite) and β-CaSiO3(β-wollastonite). m-ZrO2(monoclinic zirconia) declined the crystallization temperatures of glasses. t-ZrO2(tetragonal zirconia) increased the crystallization temperature of Ca5(PO4)3F and declined the crystallization temperature of β-CaSiO3. t-ZrO2greatly increased the fracture toughness, bending strength and micro-hardness of glass-ceramics. The nanometer apatites were induced on the surface of glass-ceramic after soaking 28 days in SBF (simulated body fluid), indicating the glass-ceramic has good bioactivity. The in vitro cytotoxicity test demonstrated the glass-ceramic has no toxicity to cell. © 2014 Elsevier B.V.