标题:Association Between Circulating Copeptin Level and Mortality Risk in Patients with Intracerebral Hemorrhage: a Systemic Review and Meta-Analysis
作者:Zhang, Ruoyu; Liu, Jin; Zhang, Ying; Liu, Qiang; Li, Tianlang; Cheng, Lei
作者机构:[Zhang, Ruoyu; Liu, Jin; Liu, Qiang; Li, Tianlang] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Geriatr, Hangzhou 310009, Zhejiang, Peoples R China 更多
通讯作者:Zhang, RY
通讯作者地址:[Zhang, RY]Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Geriatr, Hangzhou 310009, Zhejiang, Peoples R China.
来源:MOLECULAR NEUROBIOLOGY
出版年:2017
卷:54
期:1
页码:169-174
DOI:10.1007/s12035-015-9626-z
关键词:Copeptin; Intracerebral hemorrhage; Mortality; Meta-analysis
摘要:Copeptin has been identified as a biomarker of disease severity and is associated with mortality risk in several common diseases. This study sought to determine the association between circulating copeptin level and mortality risk in patients with intracerebral hemorrhage. PubMed, Web of Science, and Wanfang Medicine Database were searched for studies assessing the association between circulating copeptin level and mortality risk in patients with intracerebral hemorrhage. The pooled hazard ratio (HR) of mortality was calculated and presented with 95 % confidence interval (95 % CI). Data from 1332 intracerebral hemorrhage patients were derived from 9 studies. Meta-analysis showed that intracerebral hemorrhage patients with poor prognosis had much higher copeptin levels than those survivors (standardized mean difference = 1.68, 95 % CI 1.26-2.11, P < 0.00001). Meta-analysis of 8 studies with HRs showed that high circulating copeptin level was associated with higher risk of mortality in patients with intracerebral hemorrhage (HR = 2.42, 95 % CI 1.60-3.65, P < 0.0001). Meta-analysis of 6 studies with adjusted HRs showed that high circulating copeptin level was independently associated with higher risk of mortality in patients with intracerebral hemorrhage (HR = 1.67, 95 % CI 1.26-2.22, P = 0.0003). Our study suggests that there is an obvious association between circulating copeptin level and mortality in patients with intracerebral hemorrhage. High circulating copeptin level is independently associated with higher risk of mortality in patients with intracerebral hemorrhage.
收录类别:SCOPUS;SCIE
WOS核心被引频次:4
Scopus被引频次:4
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953307733&doi=10.1007%2fs12035-015-9626-z&partnerID=40&md5=ded8767ca0c4a3f8ea8641c69290b490
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