标题:Mussel polysaccharide α-D-glucan (MP-A) protects against non-alcoholic fatty liver disease via maintaining the homeostasis of gut microbiota and regulating related gut-liver axis signaling pathways
作者:Wu J.; Shao H.; Zhang J.; Ying Y.; Cheng Y.; Zhao D.; Dou X.; Lv H.;等 更多
作者机构:[Wu, J] School of Pharmaceutical Sciences, Shandong University, Jinan, 250101, China, Shandong Academy of Pharmaceutical Sciences, Key Laboratory of B 更多
通讯作者:Shao, H(shrsdu@163.com)
通讯作者地址:[Shao, H] Shandong Academy of Pharmaceutical Sciences, No. 989 Xinluo Street, China;
来源:International Journal of Biological Macromolecules
出版年:2019
卷:130
页码:68-78
DOI:10.1016/j.ijbiomac.2019.02.097
关键词:Dysbiosis; Gut microbiota; Gut-liver axis; Metabolism; MP-A; NAFLD
摘要:We isolated and characterized a Mussel polysaccharide, α-D-glucan (MP-A), from Mytilus coruscus earlier. In this work, the pharmacological activity and mechanisms of MP-A as an oral supplement for non-alcoholic fatty liver disease (NAFLD) were explored. High fat diet (HFD) was utilized to induce NAFLD in Sprague Dawley male rats and MP-A (0.6 g/kg) was supplemented for 4 weeks. The results showed that MP-A supplementation reduced blood lipid levels, intrahepatic lipid accumulation and NAFLD activity score in HFD-fed rats. Additionally, the analysis of 16S rDNA sequencing on gut microbiota samples revealed that HFD could induce microbial dysbiosis. However, MP-A supplementation could remodel gut microbiota structure, inhibit LPS-TLR4-NF-κB pathway activation, and restrain subsequent inflammation factors secretion. Furthermore, MP-A regulated the lipid metabolism by promoting the production of short chain fatty acids and suppressing PPAR γ and SREBP-1c expression. Our results support that MP-A can prevent against NAFLD and act as an oral supplementation for hepatoprotection via modulating gut microbiota and related gut-liver axis signaling pathways. © 2019
收录类别:SCOPUS
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061973072&doi=10.1016%2fj.ijbiomac.2019.02.097&partnerID=40&md5=d1c703ad37814df06876807e9542ee9a
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