标题：Effect of transforming growth factor-beta 1 869C/T polymorphism and radiation pneumonitis
作者：Wang, Yingtian; Wang, Xingguang; Wang, Xiyan; Zhang, Deyong; Jiang, Shujuan
作者机构：[Wang, Yingtian; Zhang, Deyong] Dongying Peoples Hosp Shandong Prov, Dept Resp Med, Dongying 257091, Shandong, Peoples R China.; [Wang, Xingguang; J 更多
通讯作者地址：[Wang, YT]Dongying Peoples Hosp Shandong Prov, Dept Resp Med, Dongying 257091, Shandong, Peoples R China.
来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
关键词：Radiation pneumonitis; transforming growth factor; meta-analysis;; polymorphism
摘要：Background: The Transforming growth factor-beta 1 (TGF beta 1) 869C/T polymorphism was associated with radiation pneumonitis (RP) susceptibility. However, the results remained controversial. Thus, a meta-analysis was conducted. Methods: Relevant studies were systematically searched by using the NCBI, Medline, Web of Science and Embase databases. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models. Results: There was a significant association between TGF beta 1 869C/T polymorphism and RP susceptibility (OR = 1.77; 95% CI, 1.27-2.47; P = 0.0007). Conclusion: This study suggested that TGF beta 1 869C/T polymorphism was a risk factor of RP.