标题：Nematicidal and insecticidal activities of halogenated indoles
作者：Rajasekharan, Satish Kumar; Lee, Jin-Hyung; Ravichandran, Vinothkannan; Kim, Jin-Cheol; Park, Jae Gyu; Lee, Jintae
作者机构：[Rajasekharan, Satish Kumar; Lee, Jin-Hyung; Lee, Jintae] Yeungnam Univ, Sch Chem Engn, Gyongsan 38541, South Korea.; [Ravichandran, Vinothkannan] S 更多
通讯作者地址：[Lee, J]Yeungnam Univ, Sch Chem Engn, Gyongsan 38541, South Korea.
摘要：Parasite death via ion channel activations is the hallmark of anthelmintic and antiparasitic drugs. Glutamate gated chloride channel (GluCl) is a prominent targets for drug selection and design in parasitology. We report several iodine-fluorine based lead activators of GluCl by computational studies and structure-activity relationship analysis. 5-Fluoro-4-iodo-1H-pyrrolo [2, 3-b] pyridine and 5-iodoindole were bioactive hits that displayed in vitro anthelmintic and insecticidal activities against Bursaphelenchus xylophilus, Meloidogyne incognita, and Tenebrio molitor. Two important findings stood out: (i) 5F4IPP induced parasite death, and interacted proficiently with Gln(219) amino acid of pentameric GluCl in docking analysis, and (ii) 5-iodoindole appeared to act by forming giant vacuoles in nematodes, which led to a form of non-apoptotic death known as methuosis. The study suggests halogenated-indoles and 1H-pyrrolo [2, 3-b] pyridine derivatives be regarded potential biocides for plant-parasitic nematodes and insects, and warrants further research on the mode of actions, and field investigations.