标题：Recent Advances in Synthetic -Glucosidase Inhibitors
作者：Liu, Zhiyang; Ma, Shutao
作者机构：[Liu, Zhiyang; Ma, Shutao] Shandong Univ, Dept Med Chem, Key Lab Chem Biol, Minist Educ,Sch Pharmaceut Sci, 44 West Culture Rd, Jinan 250012, Peoples 更多
通讯作者地址：[Ma, ST]Shandong Univ, Dept Med Chem, Key Lab Chem Biol, Minist Educ,Sch Pharmaceut Sci, 44 West Culture Rd, Jinan 250012, Peoples R China.
关键词：antidiabetic; biological activity; drug design; inhibitors;; structure-activity relationships
摘要：Over the past few years, the number of people diagnosed with type2 diabetes has increased owing to an unhealthy diet, a limited amount of exercise, and obesity. The search for novel and efficient antidiabetes agents has become an urgent task for scientists. Among the antidiabetes drugs, -glucosidase inhibitor drugs have been proven to have many advantages over other drugs, and therefore, a large number of new compounds as -glucosidase inhibitors has recently been reported. In this review, we summarize these newly found -glucosidase inhibitors and their structure-activity relationships in antidiabetic studies and provide better structures for -glucosidase inhibitors or even preclinical candidates. Beyond that, some enlightening strategies for the synthesis of relevant compounds are highlighted.