标题:Recent Advances in Synthetic -Glucosidase Inhibitors
作者:Liu, Zhiyang; Ma, Shutao
作者机构:[Liu, Zhiyang; Ma, Shutao] Shandong Univ, Dept Med Chem, Key Lab Chem Biol, Minist Educ,Sch Pharmaceut Sci, 44 West Culture Rd, Jinan 250012, Peoples 更多
通讯作者:Ma, ST
通讯作者地址:[Ma, ST]Shandong Univ, Dept Med Chem, Key Lab Chem Biol, Minist Educ,Sch Pharmaceut Sci, 44 West Culture Rd, Jinan 250012, Peoples R China.
来源:CHEMMEDCHEM
出版年:2017
卷:12
期:11
页码:819-829
DOI:10.1002/cmdc.201700216
关键词:antidiabetic; biological activity; drug design; inhibitors;; structure-activity relationships
摘要:Over the past few years, the number of people diagnosed with type2 diabetes has increased owing to an unhealthy diet, a limited amount of exercise, and obesity. The search for novel and efficient antidiabetes agents has become an urgent task for scientists. Among the antidiabetes drugs, -glucosidase inhibitor drugs have been proven to have many advantages over other drugs, and therefore, a large number of new compounds as -glucosidase inhibitors has recently been reported. In this review, we summarize these newly found -glucosidase inhibitors and their structure-activity relationships in antidiabetic studies and provide better structures for -glucosidase inhibitors or even preclinical candidates. Beyond that, some enlightening strategies for the synthesis of relevant compounds are highlighted.
收录类别:SCOPUS;SCIE
WOS核心被引频次:7
Scopus被引频次:8
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020099752&doi=10.1002%2fcmdc.201700216&partnerID=40&md5=a0d1e497e6d117968a084e37ec4e5ebe
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