标题：Alkaloids and Flavonoids as alpha(1)-Adrenergic Receptor Antagonists
作者：Li, W.; Du, L.; Li, M.
作者机构：[Li, W.; Du, L.; Li, M.] Shandong Univ, Dept Med Chem, Sch Pharm, Jinan 250012, Shandong, Peoples R China.
通讯作者地址：[Li, M]Shandong Univ, Dept Med Chem, Sch Pharm, Jinan 250012, Shandong, Peoples R China.
来源：CURRENT MEDICINAL CHEMISTRY
关键词：alpha(1)-adrenergic receptor; antagonist; natural products; alkaloids;; flavonoids
摘要：Since the subtypes of alpha(1)-adrenergic receptor have been thoroughly determined, to date medicinal chemists raise their deliberation on how to conceive selective alpha(1)-adrenergic receptor antagonist with the minimal side effects. It needs to be well recognized that natural products can exist as a significant source of drug leads, thus portraying a consequential capacity in drug design and development. The current review article would like to present a comprehensive survey on natural products, mainly including alkaloids and flavonoids, which exhibit alpha(1)-adrenergic receptor antagonistic activities.