标题:Renin-Angiotensin System Inhibitors Prevent the Recurrence of Atrial Fibrillation: A Meta-analysis of Randomized Controlled Trials
作者:Han, Min; Zhang, Yong; Sun, Shujuan; Wang, Zhongsu; Wang, Jiangrong; Xie, Xinxing; Gao, Mei; Yin, Xiangcui; Hou, Yinglong
作者机构:[Han, Min; Zhang, Yong; Wang, Zhongsu; Wang, Jiangrong; Xie, Xinxing; Gao, Mei; Hou, Yinglong] Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Card 更多
通讯作者:Hou, YL
通讯作者地址:[Hou, YL]Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Cardiol, Jinan 250014, Peoples R China.
来源:JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
出版年:2013
卷:62
期:4
页码:405-415
DOI:10.1097/FJC.0b013e3182a094a1
关键词:angiotensin-converting enzyme inhibitor; angiotensin receptor blocker;; atrial fibrillation
摘要:Objective: This study was designed to assess whether angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) could prevent the recurrence of atrial fibrillation (AF).; Methods: A systemic literature search of PubMed, EMBASE, and Cochrane Controlled Trials Register till 2012 was performed to identify randomized controlled trials involving the prevention of recurrence of AF with renin-angiotensin system blockade therapy. Subgroup analysis and meta-regression were performed. Publication bias was checked through funnel plot and Egger's test.; Results: Twenty-one randomized controlled trials including 13,184 patients with AF were identified. Overall, the recurrence of AF was significantly reduced in patients using ACEI/ARBs [odds ratio (OR), 0.43; 95% confidence interval (CI), 0.32-0.56; P < 0.00001], especially both in irbesartan subgroup (OR, 0.38; 95% CI, 0.21-0.68; P = 0.001) and in patients receiving antiarrhythmic drug (AAD) (OR, 0.37; 95% CI, 0.29-0.48; P < 0.00001), and there was no significant difference between ACEIs and ARBs (ACEIs: OR, 0.42; 95% CI, 0.31-0.57 and ARBs: OR, 0.42; 95% CI, 0.31-0.57). Moreover, it was found that the benefits of ACEI/ARBs revealed positive correlation to systolic blood pressure (regression coefficient: -0.0700257, P = 0.000) in no-AAD users.; Conclusions: ACEI/ARBs are effective on the secondary prevention of AF, especially in patients receiving AAD and suffering from hypertension.
收录类别:SCOPUS;SCIE
WOS核心被引频次:11
Scopus被引频次:12
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84886387701&doi=10.1097%2fFJC.0b013e3182a094a1&partnerID=40&md5=0f59fb0647786f2507fe4cacad755615
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