标题：Non-nucleoside anti-HBV agents: advances in structural optimization and mechanism of action investigations
作者：Liu, Na;Zhao, Fabao;Jia, Haiyong;Rai, Diwakar;Zhan, Peng;Jiang, Xuemei;Liu, Xinyong
作者机构：[Liu, N] Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Jinan Shandong, 250012, Chi 更多
通讯作者地址：[Zhan, P]Shandong Univ, Sch Pharmaceut Sci, Key Lab Chem Biol, Dept Med Chem,Minist Educ, 44 West Culture Rd, Jinan 250012, Shandong, Peoples R China.
摘要：Hepatitis B is an infectious inflammatory disease of the liver, which is caused by the hepatitis B virus (HBV). Nowadays, the dramatic development of new HBV inhibitors is focused on discovering diverse non-nucleoside compounds with either novel structures or new mechanisms of action. In this review, we focus on the recent advances in discovery, structural modifications and biological activities studies of several distinct classes of synthetic non-nucleoside small molecular compounds with new mechanisms.