标题：The construction and characterization of hybrid paclitaxel-in-micelle-in-liposome systems for enhanced oral drug delivery
作者：Li, Yimu; Chen, Zheng; Cui, Yanan; Zhai, Guangxi; Li, Lingbing
作者机构：[Li, Yimu; Chen, Zheng; Cui, Yanan; Zhai, Guangxi; Li, Lingbing] Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Jinan 250012, Shandong, Peoples R 更多
通讯作者地址：[Zhai, GX; Li, LB]Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Jinan 250012, Shandong, Peoples R China.
来源：COLLOIDS AND SURFACES B-BIOINTERFACES
关键词：Paclitaxel; Oral drug delivery; Polyion complex micelles; Liposomes;; Multidrug resistance
摘要：In this study, novel paclitaxel (PTX) loaded hybrid liposomes for oral PTX delivery were prepared through incorporating PTX loaded polyion complex micelles comprised of positively charged Pluronic F127-Polyethylenimine (PF127-PEI) copolymer and negatively charged sodium cholate (CA) into liposomes consisted of phospholipid molecules. According to the results, this kind of PTX-loaded hybrid liposomes showed improved PTX encapsulation efficiency, sustained PTX release, and enhanced PTX absorption in intestine. The mechanism for enhancing absorption was demonstrated in connection with inhibition of the efflux mediated by multidrug resistance protein, intestinal P-gp. In pharmacokinetic study, the absolute oral bioavailability of PTX loaded in hybrid liposomes had reached to 37.91%. All of these results demonstrated that the application of this novel PTX loaded hybrid liposomes is a strategy with great potential for highly effective oral PTX delivery. (C) 2017 Elsevier B.V. All rights reserved.