标题：Synthesis of novel oxime-containing pyrazole derivatives and discovery of regulators for apoptosis and autophagy in A549 lung cancer cells.
作者：Zheng LW;Li Y;Ge D;Zhao BX;Liu YR;Lv HS;Ding J;Miao JY
作者机构：[Zheng, L.-W] Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China;[ Li, Y] Institut 更多
通讯作者地址：[Zhao, BX]Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R China.
来源：Bioorganic and Medicinal Chemistry Letters
关键词：Synthesis; Pyrazole; Oxime; Apoptosis; Autophagy; A549 cells
摘要：A series of novel oxime-containing pyrazole derivatives were synthesized by the reaction of ethyl 3-phenyl-1H-pyrazole-5-carboxylate derivatives and 2-bromo-1-phenylethanone followed by the reaction with hydroxylamine hydrochloride. The structures were determined by IR, (1)H NMR, HRMS, and X-ray analysis. A dose- and time-dependent inhibition of proliferation was observed in A549 lung cancer cell after compound treatment. Inhibition of growth was mainly attributed to the autophagy induction.