标题:Synthesis of novel oxime-containing pyrazole derivatives and discovery of regulators for apoptosis and autophagy in A549 lung cancer cells.
作者:Zheng LW;Li Y;Ge D;Zhao BX;Liu YR;Lv HS;Ding J;Miao JY
作者机构:[Zheng, L.-W] Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China;[ Li, Y] Institut 更多
通讯作者:Zhao, BX
通讯作者地址:[Zhao, BX]Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R China.
来源:Bioorganic and Medicinal Chemistry Letters
出版年:2010
卷:20
期:16
页码:4766-4770
DOI:10.1016/j.bmcl.2010.06.121
关键词:Synthesis; Pyrazole; Oxime; Apoptosis; Autophagy; A549 cells
摘要:A series of novel oxime-containing pyrazole derivatives were synthesized by the reaction of ethyl 3-phenyl-1H-pyrazole-5-carboxylate derivatives and 2-bromo-1-phenylethanone followed by the reaction with hydroxylamine hydrochloride. The structures were determined by IR, (1)H NMR, HRMS, and X-ray analysis. A dose- and time-dependent inhibition of proliferation was observed in A549 lung cancer cell after compound treatment. Inhibition of growth was mainly attributed to the autophagy induction.
收录类别:SCOPUS;SCIE
WOS核心被引频次:53
Scopus被引频次:59
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-77955418372&doi=10.1016%2fj.bmcl.2010.06.121&partnerID=40&md5=2342c415f56dc43207cb80161f0b6b69
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