标题:Recent Advance in Aminopeptidase N (APN/CD13) Inhibitor Research
作者:Zhang, X.; Fang, H.; Zhang, J.; Yuan, Y.; Xu, W.
作者机构:[Zhang, X.; Fang, H.; Zhang, J.; Yuan, Y.; Xu, W.] Shandong Univ, Dept Med Chem, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China.
通讯作者:Xu, W
通讯作者地址:[Xu, W]Shandong Univ, Dept Med Chem, Sch Pharmaceut Sci, 44 W Wenhua Rd, Jinan 250012, Shandong, Peoples R China.
来源:CURRENT MEDICINAL CHEMISTRY
出版年:2011
卷:18
期:32
页码:5011-5021
DOI:10.2174/092986711797535155
关键词:Aminopeptidase N; rational drug design; inhibitors; peptidomimetics;; anti-tumor; structure activity relationship
摘要:APN is an important zinc dependent metallo-exopeptidase, which can degrade the extracellular matrix, and plays an important role in tumor invasion, metastasis and angiogenesis. it has been considered as a suitable target for anti-cancer drug design. Recently, research of structure-based APN inhibitors is becoming an interesting field, and many APN inhibitors have been reported. Here we review a series of APN inhibitors and the recent progress in this field.
收录类别:SCOPUS;SCIE
WOS核心被引频次:14
Scopus被引频次:14
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-80054862784&doi=10.2174%2f092986711797535155&partnerID=40&md5=1d0db019bb3b21a288873bed8844b9b4
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