标题：Recent advances in electrospun for drug delivery purpose
作者：Liu, Mengyao; Zhang, Yanan; Sun, Siyu; Khan, Abdur Rauf; Ji, Jianbo; Yang, Mingshi; Zhai, Guangxi
作者机构：[Liu, Mengyao; Zhang, Yanan; Sun, Siyu; Khan, Abdur Rauf; Ji, Jianbo; Zhai, Guangxi] Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan, Shandong, Peop 更多
通讯作者：Yang, MS;Zhai, GX
通讯作者地址：[Yang, MS]Univ Copenhagen, Fac Hlth & Med Sci, Dept Pharm, Univ Pk 2, DK-2100 Copenhagen, Denmark;[Zhai, GX]Shandong Univ, Sch Pharmaceut Sci, Dept Ph 更多
来源：JOURNAL OF DRUG TARGETING
关键词：Electrospun; drug delivery system; electrospraying; polymers;; electrospun nanofibers
摘要：Electrospun, an advanced technology, has been successfully employed for fibre production and offers many merits in novel drug delivery systems (DDSs). In recent years, electrospun has gained significant attention and attraction of the scientists in soaring numbers. This technology is superior to other technologies in fabricating the fibres which range from micrometers to manometers scale. The selection of appropriate polymers, electrospun processes and electrospun parameters play important roles in controlling the drug release while, treating serious illness. Besides, electrospraying process has similar characteristics to the electrospun and is presented briefly here. Further, in vivo and in vitro evaluations of the electrospun nanofibers are comprehensively discussed. In addition, the electrospun nanotechnology has been exploited to design drug release systems, investigate drug's pharmacokinetics and further develop DDS. The electrospun nanofibers improve bioactivity of various types of drugs including water-insoluble, soluble, anticancer and antibacterial drugs and genetic materials. In the end, the prospects and challenges in the process of designing drug-loaded electrospun nanofibers are discussed in detail.