标题:Glycosylation and Production Characteristics of Epothilones in Alkali-Tolerant Sorangium cellulosum Strain So0157-2
作者:Zhao, Lin; Li, Peng-fei; Lu, Chun-hua; Li, Shu-guang; Shen, Yue-mao; Li, Yue-zhong
作者机构:[Lu, Chun-hua; Shen, Yue-mao] Xiamen Univ, Xiamen Engn Res Ctr Marine Microbial Drug Discove, Minist Educ Cell Biol & Tumor Cell Engn, Fujian Lab Phar 更多
通讯作者:Shen, YM
通讯作者地址:[Shen, YM]Xiamen Univ, Xiamen Engn Res Ctr Marine Microbial Drug Discove, Minist Educ Cell Biol & Tumor Cell Engn, Fujian Lab Pharmaceut Engn,Sch Life 更多
来源:JOURNAL OF MICROBIOLOGY
出版年:2010
卷:48
期:4
页码:438-444
DOI:10.1007/s12275-010-0048-3
关键词:S. cellulosum; epothilones; glycosylation; epothiloneoside A
摘要:3-O-alpha-D-ribofuranosyl epothilone A (epothiloneoside A) is a major component of glycosylated epothilones in Sorangium cellulosum strain So0157-2. The production and glycosylation ratios of epothiloneoside A in both solid and liquid culture conditions with various pH values and carbon sources were studied. The results showed that glycosylation occurs whenever epothilones are produced, regardless of changes in pH values, production time curves, and different carbon sources. We suggest that glycosylation is a stable process, paralleling the biosynthesis of epothilones in the So0157-2 strain.
收录类别:SCOPUS;SCIE
WOS核心被引频次:11
Scopus被引频次:13
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-77956106034&doi=10.1007%2fs12275-010-0048-3&partnerID=40&md5=bbe3fb8ab79015a63f7f4ad40c981808
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