标题：Astrocyte elevated gene-1 and breast cancer (Review)
作者：Wang, Chuan; Yang, Qifeng
作者机构：[Wang, Chuan; Yang, Qifeng] Shandong Univ, Sch Med, Dept Breast Surg, Qilu Hosp, Jinan 250012, Shandong, Peoples R China.
通讯作者地址：[Yang, QF]Shandong Univ, Sch Med, Dept Breast Surg, Qilu Hosp, Wenhua West Rd 107, Jinan 250012, Shandong, Peoples R China.
关键词：astrocyte elevated gene-1; metastasis; angiogenesis; prognosis; breast; cancer
摘要：Astrocyte elevated gene-1 (AEG-1), also known as MTDH and Lyric, is a novel gene that was first cloned by subtraction hybridization in 2002 and has recently been shown to play a role as a crucial oncogene that acts as a promoter of tumor malignancy. Overexpression and inhibition studies both in in vitro and in vivo models have partly shown the oncogenic roles of AEG-1 in a number of crucial aspects of tumor development and progression, including transformation, evasion of apoptosis, proliferation, cell survival, migration, invasion, metastasis, angiogenesis and chemoresistance through the activation of numerous signaling pathways, such as the nuclear factor kappa B, PI3K/AKT, Wnt/beta-catenin and mitogen-activated protein kinase signaling pathways. However the potential roles of AEG-1, particularly in specific organs or tissues, such as breast tissue, require further clarification. Studies have found that in normal human breast tissue, AEG-1 is always expressed at low levels or is absent, while it is widely overexpressed in many breast cancer cell lines and breast tumors. The present review evaluates the current literature with regards to AEG-1 relative to breast cancer development and progression and highlights new perspectives relative to this molecule, indicating its potential to become a new target for the clinical treatment of breast cancer.