标题：Roflumilast Reduces Cerebral Inflammation in a Rat Model of Experimental Subarachnoid Hemorrhage
作者：Wu, Qingjian; Qi, Lifeng; Li, Hanxia; Mao, Leilei; Yang, Mingfeng; Xie, Rongxia; Yang, Xiaoyi; Wang, Jian; Zhang, Zongyong; Kong, Ji 更多 作者机构：[Wu, Qingjian; Qi, Lifeng] Shandong Univ, Sch Med, Dept Neurol, Jinan 250012, Shandong, Peoples R China.; [Wu, Qingjian; Li, Hanxia; Mao, Leilei; Ya 更多
通讯作者：Zhang, ZY;Sun, BL;Kong, JM
通讯作者地址：[Zhang, ZY; Sun, BL]Taishan Med Univ, Affiliated Hosp, Dept Neurol, Key Lab Cerebral Microcirculat Univ Shandong, Tai An 271000, Shandong, Peoples R C 更多
关键词：subarachnoid hemorrhage; roflumilast; cerebral inflammation
摘要：Roflumilast, a selective inhibitor for PDE4, is approved by FDA as an anti-inflammation drug for treatment of chronic obstructive pulmonary disease (COPD). This study investigates the effects of roflumilast on cerebral inflammation in the rat SAH model. Here, we show that subcutaneous administration of roflumilast (3 mg/kg) significantly improved the neurological deficits. Measurement of evans blue extravasation and brain water content revealed a significant reduction of blood-brain barrier permeability and brain edema. Importantly, roflumilast treatment remarkably decreased levels of IL-1 beta, IL-6, and TNF-alpha and the number of apoptotic neurons in the brain after SAH. These results indicate that roflumilast is effective in treating cerebral inflammation following SAH.