标题:Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3
作者:Chen, Zi-Jiang; Zhao, Han; He, Lin; Shi, Yuhua; Qin, Yingying; Shi, Yongyong; Li, Zhiqiang; You, Li; Zhao, Junli; Liu, Jiayin; Lia 更多
作者机构:[Chen, Zi-Jiang; Zhao, Han; Shi, Yuhua; Qin, Yingying; You, Li; Bian, Yuehong; Gao, Xuan; Geng, Ling; Yan, Junhao; Li, Yuan; Ma, Jinlong; Zhao, Yueran 更多
通讯作者:Chen, ZJ
通讯作者地址:[Chen, ZJ]Shandong Univ, Shandong Prov Hosp, Ctr Reprod Med, Jinan 250100, Shandong, Peoples R China.
来源:NATURE GENETICS
出版年:2011
卷:43
期:1
页码:55-U75
DOI:10.1038/ng.732
摘要:Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P-value by meta-analysis P-meta = 7.55 x 10(-21), odds ratio (OR) 0.71); 2p21 (rs13429458, P-meta = 1.73 x 10(-23), OR 0.67); and 9q33.3 (rs2479106, P-meta = 8.12 x 10(-19), OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended.
收录类别:SCOPUS;SCIE
WOS核心被引频次:286
Scopus被引频次:305
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-78651256136&doi=10.1038%2fng.732&partnerID=40&md5=d1c71844848d48ca76c93a8c08a4e155
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